The dogs and cats protecting Burden Hill from supernatural harm find themselves facing new threats and mysteries, including a vengeful demon, an invisible killer, and an enigmatic flock of lost sheep. As a growing evil threatens to overwhelm their town, the animals find themselves some unlikely allies, most notably a seasoned paranormal investigator named . . . Hellboy.

This volume collects the comic-book series Beasts of Burden: Sacrifice, Beasts of Burden: Neighborhood Watch, Beasts of Burden: Hunters and Gatherers, Beasts of Burden: What the Cat Dragged In, and Beasts of Burden: The Presence of Others #1 and #2.